In the Cornell University of New York, USA they did a study to determine the basic oral pharmacokinetics and assess safety and analgesic efficacy of a cannabidiol (CBD) based oil in dogs with osteoarthritis (OA). Single-dose pharmacokinetics was performed using two different doses of CBD enriched (2 and 8 mg/kg) oil. Thereafter, a randomized placebo-controlled, veterinarian, and owner blinded, cross-over study was conducted. Dogs received each of two treatments: CBD oil (2 mg/kg) or placebo oil every 12 h. Each treatment lasted for 4 weeks with a 2-week washout period.
The results show that the CBD oil treatment in the dosage 2mg/kg gives a significant decrease in pain and increase in activity in the time period that they received the treatment. Also no side effects were reported by the owners. Although, serum chemistry showed an increase in alkaline phosphatase during the CBD treatment.
Wakshlag, J.J., Frye, C.F., Gamble, L.J., Boesch, J., Schwark, W.S., Brown, H., Wolfe, L., Mann, S. and Berthelsen, E.S., 2018. “Pharmacokinetics, safety, and clinical efficacy of cannabidiol treatment in osteoarthritic dogs.” Frontiers in Veterinary Science, 5, p.165.