KEY TAKEAWAYS:

• n-6 and n-3 polyunsaturated fatty acids (PUFA) are essential and extremely important for the well-being and healthy development of dogs
• Apart from its direct benefits, the presence of n-3 PUFA in the diet allows obtaining other benefits such as anti-inflammatory. 
• Linolenic (n-6) and α-linolenic (n-3) acid cannot be produced by dogs and are therefore fundamental in a dog’s diet
• The study showed that the hempseed cake supplement had a higher crude protein and fiber content than the compared animal lipid source 
• The hempseed supplement showed a healthier fatty acid profile, with a higher concentration of PUVA, linolenic and α-linolenic acid and in a ratio ideal for dogs’ health and optimal for reduction of certain diseases, like cancer and sudden cardiac death 
• After 1 month of diet supplementation with hempseed cake, dogs experienced a reduction in liver and renal markers 
• Improvement of other hematological parameters, such as cholesterol, after the hempseed diet, confirmed that the addition of hempseed cake is safe for dogs to consume

KEY TAKEAWAYS:

• Previous findings report CBD’s ability to inhibit tumor invasion and cancer metastasis
• 50% of dogs over 10 years of age have cancer and 20% of cats will develop cancer in their lifetime
  
• Superior tumor cell killing was achieved with CBD than with 4 Gy (unit of radiation dose) of RT alone
• Results support a greater effectiveness in killing tumor cells when combining CBD and radiotherapy (RT)
• CBD use in combination with RT increased the survival rates of the studied mice
• There is a clear demonstration of a bigger survival rate of CBD-treated mice comparing with the control group (no treatment)
• In situ (in the exact local) delivery of CBD with smart biomaterials allows bigger concentrations of CBD to reach its target
• CBD treatment occasioned an 80% survival rate (vs 50% in the control group) in mice with tumors, whereas the use of smart biomaterials loaded with CBD resulted in a 100% survival rates 

KEY TAKEAWAYS:

• Epilepsy causes anxiety, fear, cognitive impairment and reduces life expectancy in dogs
• Epilepsy is the most common chronic neurological condition among dogs 
• CBD treatment is in the top 3 of highest potential positive impact on epilepsy management in dogs, among nondrug therapies
• 77% of responders reported that CBD had a positive impact in controlling epilepsy

KEY TAKEAWAYS:

• Joint destruction in arthritis is driven by a series of inflammatory molecules, of which TNF-α is a major player
• CBD induced a 97% reduction in the secretion of TNF-α in human cells
• Influx of immune cells was reduced by more than 80% after topical CBD application, whereas TNF-α production was reduced by 50%.
• Cannabidiol treatment significantly reduced the development of edema 
• When injected into mice models, CBD caused an increase of anti-inflammatory molecules

KEY TAKEAWAYS:

• Long-term use of cannabinoids was well tolerated and no loss of effect was perceived
• Patients on treatment did not seek to increase cannabinoids dose nor did they seek any other treatment for pain relief
• Quality of life domains of insomnia, fatigue and pain showed an improvement after cannabinoid administration and no harmful effect was observed in the domain of cognitive functioning

KEY TAKEAWAYS:

• CBD is a cannabinoid whose effects are exerted via two types of receptors, CB1 and CB2 that take part in the endocannabinoid system 
• The endocannabinoid system may be a target for treatment of immune-mediated and inflammatory disorders such as allergic skin diseases in dogs
• Dermatitis is a major medical issue in the field of veterinary medicine, and atopic dermatitis (AD) a common condition in dogs; no single treatment is universally effective.
• The cannabinoid receptors are overexpressed in AD, making them a target for treatment
• This study reports that cannabinoids, such as CBD, can be a treatment option for AD and other inflammatory diseases in companion animals

KEY TAKEAWAYS:

• 50 mg/day of CBD or 20 mg/day of liposomal CBD significantly reduced pain in dogs suffering from osteoarthritis
• Packaging CBD within a liposome (delivery method) forms liposomal CBD and improves CBD’s bioavailability and absorption 
• Movement indexes (standing, walking and running) were all improved after administration of both 50mg/day CBD and 20 mg/day liposomal CBD
• Dog’s quality of life increased after CBD treatment
• The study supports the safety and therapeutic potential of CBD for relieving arthritic pain and improving dog’s activity levels
• No detrimental impact of CBD administration was reported

KEY TAKEAWAYS:

• 43% of participants experienced a  ≥30% reduction in cancer-related pain intensity after cannabinoid treatment 
• 20% of cats and 25% of dogs will be diagnosed with cancer in their lifetime
• After 2 weeks of receiving CBD+THC in addition to all other treatments, there was a statistically significant reduction in pain severity when compared with placebo
• The addition of CBD resulted in a increase of 20% in the response rate 
• A greater proportion of patients in the cannabinoid treatment group reduced other pain medication doses whereas the highest proportion of increases in dose was in the placebo group
• Administration of THC+CBD was well tolerated and no safety concerns were identified 

KEY TAKEAWAYS:

• Oral CBD administration didn’t alter the overall activity in adult dogs
• Contrary to reports on possible sedative and hypnotic effects of CBD, this study didn’t confirm any of these claims
• Administration of CBD reduced scratching duration, highlighting a benefit in its use to treat skin diseases and pruritic disorders
• No adverse events were observed in any dogs following CBD administration 

KEY TAKEAWAYS:

• After CBD administration, aggressive behavior towards humans showed a significant decrease 
• Fear and anxiety are a common cause of aggressive conducts in dogs 
• Dogs in the study did not show any of the symptoms referable to CBD intolerance
• CBD treatment did not decrease the activity nor level of attention towards the environment of the dogs studied, as already highlighted for other species 
• The positive outcomes in this defiant environment are promising for more friendlier ones 

KEY TAKEAWAYS:

• CBD reversed hyperalgesia after 7 days of oral treatment in 2 models of persistent pain in rats
• Repeated administration of CBD oil abolished/reduced the levels of molecules implicated in the pathogenesis of many inflammatory disorders and pain installation
• The study put into evidence the anti-hyperalgesic potency of CBD, while being a non-toxic and non-psychotropic agent 

KEY TAKEAWAYS:

• 79.2% of the patients exhibited an improvement in anxiety in the 1st month 
• The decrease of anxiety levels was sustained during the rest of the treatment period
• 66.7% of the population experienced less sleep-related problems in the 1st month
• The mean anxiety score dropped from 23.87 to 16.36 in the population whose primary concern was anxiety
• The patients presenting with a primary concern of sleep had a reduction from 13.08 to 9.33 in the mean sleep-problems score