Candid Summaries on CBD Studies

KEY TAKEAWAYS:

• TNF-α is a proinflammatory molecule with increased expression and present in high pathological levels in canine atopic dermatitis
• IL-6 (proinflammatory molecule) production is boosted in atopic dermatitis and its blockage can help improving this disease
• Both TNF-α and IL-6 are associated with the pathogenesis of arthritis in dogs 
• CBD reduced the secretion of TNF-α and IL-6 (molecules that drive the inflammatory response) in an ex vivo model of inflammation in canine blood cells
• The TNF-α to IL-10 (pro-inflammatory molecule) ratio is a marker of the balance between key pro- and anti-inflammatory levels
• Treatment with CBD restored the TNF-α to IL-10 ratio to a healthy balance 
• CBD also reduced NF-κB activation (NF-κB is a regulator of the inflammatory response and of many pro-inflammatory cytokines)
• Finally, administration of CBD to the inflamed cells resulted in a lower COX-2 (which is upregulated in inflammation) expression 

KEY TAKEAWAYS:

• Canine atopic dermatitis (AD) is a multifactorial allergic disease that affects up to 27% of dogs and is associated with immune dysfunction and abnormal skin barrier
• Due to elevated costs and side effects of traditional medication, natural treatments are constantly being developed
• Cannabidiol was able to downregulate key actors involved in the development and progression of this dermatological disease
• Treatment with CBD + polyphenols showed an ability to revert the overexpression of canine AD key inflammatory genes
• This study’s results provide groundwork for CBD application in sustained drug therapy or relapse prevention in atopic dermatitis

KEY TAKEAWAYS:

• The endocannabinoid system participates in skin equilibrium via CB1 and CB2 and TRPV receptors
• Pre-clinical studies illustrate evidence of the hair regrowth benefits of antagonizing the CB1 receptors and over stimulating TRPV1 with CBD
• CBD has also been shown to result in hair elongation and to maintain the hair follicle in the growing phase of the hair cycle
• The study showed a 93.5% increase in nonvellus (new) hair after six months of treatment with topical CBD
• No side effects were reported 
• Growth of new hair it’s a way of reviving and replacing the damaged hair in your dog's fur
• New hair is healthier, shinier and softer than old damaged hair, since it hasn't been in contact with the harmful stimuli of the environment 

KEY TAKEAWAYS:

• CBD is a cannabinoid whose effects are exerted via two types of receptors, CB1 and CB2 that take part in the endocannabinoid system 
• The endocannabinoid system may be a target for treatment of immune-mediated and inflammatory disorders such as allergic skin diseases in dogs
• Dermatitis is a major medical issue in the field of veterinary medicine, and atopic dermatitis (AD) a common condition in dogs; no single treatment is universally effective.
• The cannabinoid receptors are overexpressed in AD, making them a target for treatment
• This study reports that cannabinoids, such as CBD, can be a treatment option for AD and other inflammatory diseases in companion animals

KEY TAKEAWAYS:

• Oral CBD administration didn’t alter the overall activity in adult dogs
• Contrary to reports on possible sedative and hypnotic effects of CBD, this study didn’t confirm any of these claims
• Administration of CBD reduced scratching duration, highlighting a benefit in its use to treat skin diseases and pruritic disorders
• No adverse events were observed in any dogs following CBD administration