Candid Summaries on CBD Studies

KEY TAKEAWAYS:

• During CBD treatment, dogs’ pain decreased with pain scores dropping from 21 to 14 (0-50 scale)
• Use of CBD oil result in a 12% increase in dogs’ activity 
• No side effects were reported by owners.  
• These clinic results suggest that the use of 2 mg/kg CBD twice a day can increase the comfort and activity of dogs suffering from osteoarthritis 

KEY TAKEAWAYS:

• This study brings to light the safety profile of CBD for both dogs and cats
• CBD administration had no effect on food intake and body weight
• No abnormal physical examinations, changes in behavior or organ dysfunction were detected after CBD administration in both dogs and cats
• The administration of 4mg/kg of CBD daily to dogs and cats was well tolerated and not harmful 
• CBD consumption by healthy dogs and cats did not alter blood analysis nor serum chemistry, supporting the secure and harmless profile of CBD 
• Once again, this study provides foundation for the therapeutic use of CBD, since its properties have been vastly demonstrated and its safety evaluated

KEY TAKEAWAYS:

• Dogs treated with CBD had a significant reduction in seizure frequency, compared with the placebo group 
• No adverse behavioral effects were reported by owners 
• CBD had no reported proconvulsive effects
• Side effects like somnolence, loss of appetite, and diarrhea were not reported in the present study

KEY TAKEAWAYS:

• CBD oil administration had little effect on food intake and physical activity 
• There was no difference in the adverse effect profile of CBD oil when compared to its control group
• Administration of CBD oil up to a dose of 62mg/kg per day resulted in mild side effects only and these side effects were also detected in the corresponding placebo group
• No moderate or clinically significant adverse effects were reported after  administration of CBD oil up to 62mg/kg daily
• The study provides novel data that separates the safety and tolerability of dose escalation of oil formulations predominant in CBD, THC, or CBD + THC (1.5:1) 
• There was a clear distinction in the safety profile of the CBD oil when compared to THC or CBD+THC oil, with CBD oil being the most well tolerated
• The study supports the safe and tolerable profile of CBD oil even when administered up to 62mg/kg daily, which is considered a much higher dose than would be anticipated for clinical use
• Normally recommended doses range from 0.5 to 8mg/kg

KEY TAKEAWAYS:

• Repeated CBD administration was well tolerated by dogs and no clinically relevant changes were observed related to the administration of any dose of CBD
• Veterinary examinations revealed no clinically important abnormal findings
• No observable differences between groups were detected in motor activity, ophthalmologic examinations, systolic arterial blood pressure (SAP), ECG and complete blood count (CBC) analysis 
• All adverse effects were mild and self-limiting, required no intervention, and occurred across all treatment groups, including the placebo group
• There was a greater frequency in side effects in the 12mg/kg group with hypersalivation being the most common one
• The most notable change was the increase in serum ALP (liver enzyme) activity; these increases began to decrease after 2 weeks of treatment and not all dogs developed this change, suggesting that such increase may not be a hallmark of CBD administration but an adaptive response. The dogs that had higher ALP activity didn´t show any sign of hepatocellular degeneration indicating it is an adaptive rather than adverse response to drug exposure

KEY TAKEAWAYS:

• 50 mg/day of CBD or 20 mg/day of liposomal CBD significantly reduced pain in dogs suffering from osteoarthritis
• Packaging CBD within a liposome (delivery method) forms liposomal CBD and improves CBD’s bioavailability and absorption 
• Movement indexes (standing, walking and running) were all improved after administration of both 50mg/day CBD and 20 mg/day liposomal CBD
• Dog’s quality of life increased after CBD treatment
• The study supports the safety and therapeutic potential of CBD for relieving arthritic pain and improving dog’s activity levels
• No detrimental impact of CBD administration was reported

KEY TAKEAWAYS:

• Oral CBD administration didn’t alter the overall activity in adult dogs
• Contrary to reports on possible sedative and hypnotic effects of CBD, this study didn’t confirm any of these claims
• Administration of CBD reduced scratching duration, highlighting a benefit in its use to treat skin diseases and pruritic disorders
• No adverse events were observed in any dogs following CBD administration